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Much worksuggests that a variety of neurocognitive functions declinewith aging, even in those without demonstrable neurologi-cal disease (although the enormous difficulty in removingpreclinical AD completely from one’s aging cohort/controlgroup, plus the ubiquitous penetration of vascular disease inWestern societies raises serious questions about how manystudies purporting to show age-related cognitive changemay be measuring at least in part prodromal stages of neu-rological decline from a major disease of aging). Pharmacologic treat-ment of GI infections alone is estimated to cost upwards of million annually in UnitedStates

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